The original abstracts of the XXVII International Symposia on Morphological Science (4-7 June 2020) will be published in the Journal Annals of Anatomy.
For more than a century the Annals of Anatomy have been one of the most famous and widespread journals on morphology. The journal is the official journal of the Anatomische Gesellschaft (Anatomical Society).
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- Language: English
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Variants of kidney veins
Aru D.Balmagambetova1*, Daniel L. Wall 2, Gulmira A.Zhurabekova3
1Department of Normal Anatomy, West Kazakhstan Marat Ospanov state medical university, Aktobe, Kazakhstan;
2Centre for Blood Cell Therapies, Peter MacCallum Cancer Centre, Melbourne, Australia;
3Department of science, West Kazakhstan Marat Ospanov state medical university, Aktobe, Kazakhstan
THE OVARIAN RESERVE INDEXES IN WOMEN LIVING IN THE ARAL SEA ENVIRONMENTAL DISASTER REGION.
Aru Balmagambetova1*, Gulmira Zhurabekova1
1 Department of Normal and Topographical Anatomy with Operative Surgery, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
BACKGROUND: To date, the Aral Sea disaster constitutes the global environmental problem for Kazakhstan. Numerous scientific studies reflected a high incidence rate in the population living in this region associated with the organochlorine pesticides. They belong to the group of “endocrine disruptors”, which can be incorporated into the normal cycle of steroidogenesis, leading to cellular damage and disrupting the maturation and fertilization of oocytes. It has been found that in regions with a high content of these compounds, reproductive capabilities in population are reduced due to morphofunctional changes at the organs level.
METHODS: The present case-control study included 108 women aged 27-40 years, where participants living in the city of Aktobe served as controls for women living in Shalkar district, which was referred to zone 1 (1 of 3) of the Aral Sea disaster. Examination of women was carried out on 3-5th (beginning of the follicular phase) and 11-13th days (end of the follicular phase) of the menstrual cycle with the ultrasound study of the ovaries (determination of the ovarian volume and counting the number of antral follicles) with dopplerography of the ovarian vessels and the AntiMullearian hormone (AMH) level determining. Statistical processing was performed through the Student’s T-test, Mann-Whitney U-test, Spearman’s rank correlation (r).
RESULTS: In the studied group, the volume of the left ovary was reduced by 12.7%, the volume of the right ovary by 25.4% compared to the baseline data at the beginning of the menstrual cycle follicular phase. At the end of the follicular phase there was a similar decrease, in the left ovary by 18.5%, and in the right ovary 32.9%, respectively. Besides, the volume of the cortical substance of both ovaries in the studied group was reduced by 2.01 and 2.2 times at the beginning of the follicular phase and by 2.4 and 3.01 times at the end of the follicular phase, respectively, compared to women from the control group. In the studied group the number of antral follicles in the left ovary was reduced by 7.5%, in the right ovary by 41.4%, compared to control group at the beginning of the follicular phase. At the end of the follicular phase, the number of antral follicles in the left ovary was reduced by 15%, in the right ovary by 34.4% compared to the control group. These two valuable ultrasound indicators, such as the volume of the ovaries and the number of antral follicles, clearly demonstrate a decrease in ovarian reserve in the group of women living in the Aral Sea region. In addition, the functional deficit was most expressed in the right ovary, while the function of the left one was close to normal. The level of the AMH marker in the studied group was reduced by 59% compared to control group, thus showing a decrease in the ovarian reserve.
CONCLUSIONS: Positive correlation of the findings on the ovaries ultrasound data and the AMH index evidence a relationship between the morphological parameters of the organ, such as the ovaries volume as well as the number of antral follicles, and the hormone determining the ovarian reserve’s level. All these rates were significantly reduced in women of the Aral Sea region, thus proving the role of environmental factors on the functional activity of the organ.
PRIMARY CILIARY DYSKINESIA (KARTAGENER SYNDROME) – A CASE REPORT.
Aliyeva1*, S. Akhmetova1, G. Kachkinbayeva2, A. Lugovaya1, M. Mambetalina2
1West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan;
2Nazarbayev intellectual school, Aktobe, Kazakhstan
BACKGROUND: According to literary sources, more than 50 hereditary syndromes are described, including the reverse arrangement of organs. One of these, Sievert syndrome - Cartagena with a triad of symptoms: reverse arrangement of internal organs, chronic bronchopulmonary process and rhinosinusopathy. According to the world Register of Rare Diseases OMIM, frequency of occurrence of this pathology is 1:50,000 newborns. According to modern concepts, Cartagener syndrome is considered one of the variants of primary ciliary dyskinesia.
CASE REPORT: Patient A., 11 years old, treated in the Children’s Clinical Hospital of Aktobe with a diagnosis: “Congenital malformation, community-acquired bronchopneumonia, acute uncomplicated course. Acute rhinopharyngitis. Acute bilateral catarrhal otitis media. Sievert-Cartagener Syndrome”. Family heredity was not burdened. A child was born after the 2nd pregnancy (1st was interrupted). Body weight at birth was 3,400 gr and height 52 cm. Pregnancy proceeded with marked gestosis. The child since the first birth up days was directed in the neonatal pathology department with a diagnosis of pneumonia. Throughout the medical record mentions of frequent recurrences of respiratory diseases were found. At the last admission to hospital cough with serous-purulent sputum, shortness of breath (24 per min.), pain in the abdomen, ears, persistent fever (39°C) were observed. An increase in the ESR up to 20 mm/h., leukocytosis up to 11.5x109 were noted in the blood test. On the review of the chest radiograph dextracardia, strengthening of the vascular pattern was noted in the medial zones on both sides. An echocardiographic study revealed an additional chord in the left ventricular cavity. The ejection fraction was 66%. Minimal mitral and small tricuspid regurgitation presented. On computed tomography of the organs of the thoracic and abdominal cavities dextracardia was detected, but the heart was not dilated in diameter. The inferior vena cava fell into the left right atrium. The hepatic vein flowed into the left atrium to the left, isolated from the inferior vena cava. The right lung was located on the left, the left lung was on the right. The abdominal organs were “mirrored”, the spleen was lobed. ECG conclusion: sinus arrhythmia with a heart rate of 65-100 in a minute. Ultrasound of the abdominal organs showed the situsvisceruminversus. There were no structural changes by organs, the sizes corresponded to the age. Consultation of the ENT specialist: bilateral catarrhal otitis media. Loss of hearing, first degree. The reverse position of an organ relatively to its own axis or median plane of the body is the result of an early violation of embryonic rotation or a consequence of a violation of the ovum differentiation. In the early embryonic period, the internal organs are located along the midline of the body. Normally, in the course of their subsequent development, growth and rotation take place to the right, extremely rarely when the situsvisceruminversus is to the left. This clinical case of the abnormal position of the organs of the thoracic and abdominal cavities lead to a chronic inflammatory process that requires high vigilance in the diagnosis and the choice of further treatment tactics.